Eye drop filtration solution


 

Ophthalmic preparations, from contact lens cleaning and storage solutions to rinsing solutions in ophthalmic surgery and eye treatment products, must meet stringent regulatory requirements and product specifications.
The majority of eye drops consist of water. In addition, there may be salts such as sodium chloride, preservatives, petroleum jelly for the production of ointments, and gel polymers for lubricants. Heat-sensitive ophthalmic solutions can be sterilized by sterile filtration or by adding sterilizing components to pre-sterilized bulk solutions.

 

Separation Target

● Pre-filtration
Reduce particulate matter and bioburden before sterile filtration

● Sterile filtration
Reliable and long-term retention of microorganisms

 

Application Requirements

● Filters must provide consistently high flow rates and be robust to meet the demands of large-scale manufacturing processes

● Sterile filters must reliably retain microorganisms over time.
● Filters must be free from adsorption or binding and robust to meet the demands of large-scale production of preservatives in product manufacturing

 

Recommendation

Filtration Steps

Recommendation

Pre-filtration

PP, MCE, GF

Sterile Venting

PTFE

Final Filtration

PES

Plasma separation filtration

Small-volume parenteral (SVP) injection