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Pilot batch processing

Category:

Hollow fiber membrane filter

Pharmaceutical industry

Clarification

Concentrated

Filter Material

Modified polyethersulfone

Features and Advantages

High Pressure Resistance

High Temperature Resistance

Strong Anti-pollution Ability

High Throughput

Application Areas

Contact Number: 19564072084

Inquire Now

Product Details

Product Applications

Cell concentration, clarification and diafiltration

Lysate clarification

VLP and virus purification, concentration and diafiltration

Protein purification, concentration and diafiltration

Nucleic acid diafiltration and concentration

Nanoparticle and latex particle diafiltration and fractionation

Bacteria concentration and diafiltration

Liposome, siRNA concentration and diafiltration

Bioreactor perfusion and media exchange

Hollow fiber filter modules are manufactured by encapsulating hollow fibers within a housing. The housing has end caps, each including two ports, totaling one feed port, one retentate port, and two permeate ports. Ports utilize different types and sizes of adaptors and fittings. The hollow fiber length is consistent with the housing, running from the feed port to the retentate port. During use, the feed liquid is pumped from the feed port under the pressure of the pump. Most of the feed liquid flows through the hollow fiber and exits from the retentate port. Another part of the feed liquid passes through the hollow fiber wall, enters the housing, and then exits from the permeate port.

Filter Component Materials

Hollow fiber membrane: Modified polyethersulfone

Support net (if any): Polypropylene

Housing, end caps and external plastic parts: Polysulfone

Potting material: Polyurethane or epoxy resin

Seals or gaskets: Platinum-cured silicone

Cross-sectional view of the hollow fiber filter module, showing the structural materials of each component of the filter module

1-Polysulfone housing and end fittings

2-mPES hollow fiber

3-Polyurethane or epoxy resin potting

4-Spectrum Label

5-Product Label

Hollow Fiber Design

The membrane used to manufacture mPES hollow fibers is seamless and structurally heterogeneous.

The dense skin layer of the mPES membrane reduces the possibility of contamination, while the relatively open outer support structure increases the filtration rate.

100X (upper image) and 750X (lower image) magnification of the hollow fiber cross-section, showing the seamless structure.

Cross-section of 30kD 0.5mm ID mPES hollow fiber, magnified 100 times

Cross-section of 30kD 0.5mm ID mPES hollow fiber, magnified 750 times

Product Performance

Low bioburden

100% integrity testing

Biocompatibility and animal-origin-free characteristics compliant with USP Class VI standards

Manufactured in an ISO Class 7 cleanroom, in accordance with ISO9001:2008 quality management system requirements

Product Series

Pilot batch processing

Permeate volume: 5 L –50 L

Fittings: 11/2”TC × 3/4”TC

Effective length: 20, 41.5 & 60 cm

Surface area: 1650 cm2–10000 cm2

Standard Water Flux

Standard water flux (NWP) is the water flow rate (LMH) divided by TMP. NWP can be calculated by dividing the actual measured LMH

by TMP. The minimum NWP requirements for different MWCO mPES filters are shown in the table below.

0.5mm fiber			1mm fiber
mPES Hollow Fiber Specifications	WP (L/m2H/psi)	mPES Hollow Fiber Specifications	WP (L/m2H/psi)
3kD	≥2.5	3kD	≥2.5
5kD	≥3.0	5kD	≥3.0
10kD	≥5.0	10kD	≥5.0
30kD	≥20	30kD	≥20
50kD	≥30	50kD	≥30
70kD	≥50	70kD	≥40
100kD	≥80	100kD	≥60
300kD	≥100	300kD	≥100
500kD	≥100	500kD	≥100

Increasing the surface area of the hollow fiber filtration system

1. Increase the number of fibers

2. Increase the length of the fibers

3. Increase both the number and length of the fibers

Keywords

Pilot batch processing

VF virus filter

Small batch processing

VF virus filter

Small batch processing

Pilot batch processing

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