VF virus filter
Category:
Filter Material
Asymmetric polyethersulfone (PES) hollow fiber membrane
Features and Advantages
High Pressure Resistance
High Temperature Resistance
Strong Anti-pollution Ability
High Throughput
Application Areas
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Product Details
| Product Features | Typical Applications |
|
o Hollow fiber design) Low dead volume, small footprint ◎ Small rinse volume, high recovery rate ◎ Single-use, no cleaning validation required ◎ Pre-sterilized packaging, ready to use High throughput, 300 LMH@2 bar ◎ Water-based integrity testing ◎ Maximum pressure resistance 5 bar ◎ 100% integrity testing before leaving the factory o Robust virus removal capability |
◎ Monoclonal antibody o Bispecific antibody ◎ Fc fusion protein o Nanobody ◎ Recombinant COVID-19 vaccine ◎ Small molecule recombinant protein (<180 kD), etc. |
Membrane Material Characteristics
The VF virus removal filter uses an asymmetric polyethersulfone (PES) hollow fiber membrane with a nominal pore size of 20 nm. The pore size distribution of this membrane is funnel-shaped, so the membrane can maintain high throughput while ensuring the retention of small viruses under challenging conditions without affecting the filtration of the target protein.
Patented Modification Technology
We have also specially modified the membrane surface of the VF virus removal filter using patented modification technology to reduce the adsorption of proteins, polymers, or other potential contaminants, thereby achieving a higher level of loading.
Loading Level of VF Virus Removal Filter
Water Flux Test of VF Virus Removal Filter
Retention Level of PPV in |gG
Retention Level of PP7 under Different Clogging Conditions
Retention Level of PP7 under Different Pressures
Retention Level of PP7
Retention Level of MuLV
Retention Level of MVM
| Product Parameters Product Model | VF-S | VF-U | VF-M | VF-P | ||
| Filtration Area | 0.0005 m2 | 0.02 m2 | 1 | 2 | 2 m2 | |
| Applicable Scale | Process Development | Scale-up Studies | Production Scale | Production Scale | ||
|
Filter Material |
Membrane Material | Polyethersulfone | ||||
| Housing, End Caps | Polysulfone | |||||
| Sealing Glue | Polyurethane | |||||
| Cutoff Pore Size | 20 nm | |||||
| Integrity Test | Air diffusion flow, water wetting | |||||
| Maximum Operating Pressure | 5 bar | |||||
| Maximum Tolerable Temperature | 40 ℃ | |||||
| PH Range | 4 ~ 9 | |||||
|
Interface |
Inlet, Outlet | Luer connector | TC3/4" sanitary fitting | TC1.5" sanitary fitting | TC2" sanitary fitting | |
| Outlet | Luer connector | 1/4" Pagoda connector | TC1/2" sanitary fitting | TC1" sanitary fitting | ||
| Recommended Processing Volume | < 0.5 | < 50 | > 50 | > 50 | ||
| Sterilization Method | Gamma irradiation | |||||
| Bacteriophage Retention | Minimum challenge level for PP7 bacteriophage 107 pfu/mL, LRV 4 | |||||
| TOC/Conductivity/PH @ 25℃ | Rinse volume reaches 10 L/m2 or more, filtrate conductivity < 1.3 μS/Cm, TOC < 500 ppb, PH range 5.0 ~ 7.0 | |||||
| Bacterial Endotoxins |
According to the 2020 edition of the Chinese Pharmacopoeia, Part IV, General 1143 Bacterial Endotoxin Test (same as USP <85>) gel method test, Eluate bacterial endotoxin content < 0.25 EU/mL |
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| USP <87> In vitro biocompatibility | USP <87> MEM elution test showed no potential cytotoxicity | |||||
| USP <88> In vivo biocompatibility | Complies with the current USP <88> Class V plastic reaction test standard (70℃ extraction) | |||||
| No animal origin | The product does not contain animal-derived components and has no risk of transmissible spongiform encephalopathy (TSE) | |||||
| Quality Assurance | The R&D and production of the product are carried out under the ISo6 9001:2015 quality management system | |||||
Ordering Information
Keywords
VF virus filter
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